----------------------------------------------------
        Isomers and derivatives of THC
----------------------------------------------------

 d1-THC : Tetra-hydro-cannabinol ==> Our friend!

                H
               HCH          OH
                 \     H     \     H     H H H H
                  C===C       C---C       C   C
               H /     \     //   \\     / \ / \
                C      HC---C       C---C   C  HCH
               H \     /     \     /   H H H H  H
                 HC---CH      C===C
                  H    \     /     H
                        C---O
                       / \            C  H  O
                     HCH HCH           21 30 2
                      H   H


                Me          OH
                 \           \
                  C===C       C---C
                 /     \     //   \\
                C       C---C       C---Pentyl
                 \     /     \     /
                  C---C       C===C
                       \     /
                        C---O
                       / \            C  H  O
                      Me  Me           21 30 2

Same again: (I'll use this format from now on.)

-----------------------------------------------------

                Me          OH
                 \           \
                  C---C       C---C
                 //    \     //   \\
                C       C---C       C---Pentyl
                 \     /     \     /
                  C---C       C===C
                       \     /
                        C---O
                       / \            C  H  O
                      Me  Me           21 30 2

 d1(6)-THC : an isomer with significantly more heat stability,
             and approximately equivalent biological activity.

----------------------------------------------------

                Me          OH
                 \           \
                  C===C       C---C
                 /     \     //   \\
                C       C---C       C---Pentyl
                 \     /     \     /
                  C---C       C===C
                       \     /
                        C  HO
                      // \            C  H  O
                    H C   Me           21 30 2
                      H

 Cannabidiol: inactive isomer of THC often present in equivalent or
              greater concentrations than THC itself. Can be easilly
              isomerized into d1(6)-THC.

-----------------------------------------------------

                Me          OH
                 \           \
                  C---C       C---C
                 //   \\     //   \\
                C       C---C       C---Pentyl
                 \     /     \     /
                  C===C       C===C
                       \     /
                        C---O
                       / \            C  H  O
                      Me  Me           21 30 2

Cannabinol : oxidation product of THC, inactive.
-----------------------------------------------------




                Watch this space for more;

                Peter Jordan
                (pjordan@amisk.cs.ualberta.ca)