an excerpt from book I of PiHKAL from alexander shulgin.
Extentions and commentary section of notes on "MME",
2,4-DIMETHOXY-5-ETHOXYAMPHETAMINE

This is one of the very few compounds with
   which I actually risked (and took) the lives of experimental animals.
   I was still impressed by the scientific myth that pharmacological
   research wasn't really acceptable without animal support data. And I
   had access to an experimental mouse colony at the University. I
   injected one mouse with a dose of 300 mg/Kg., i.p. That sounds pretty 
   scientific. But what it really means is that I picked up a mouse by
   the scruff of the back with my left hand, then turned my hand over so
   that the mouse was belly-up. I put the ring finger over a hind leg to
   keep things relatively immobile. Usually at this point there is a
   little urine evident where there had been none before. And I took a
   syringe equipped with a very fine needle and containing about 8 
   milligrams of MME in a fraction of a mL of a water solution and pushed
   that needle into the mouse at about where the navel would be if one
   could see the mouse's navel, and then I pulled the needle back just a
   little so that there should be nothing at the business end but the 
   loose folds of the peritoneum. Then I pushed the syringe plunger home,
   effectively squirting the water solution into the area that surrounds 
   the intestines. I dropped the mouse back into his cage, and watched.
   In this case, the mouse went into a twitching series of convulsions 
   (known as clonic in the trade) and in five minutes he was dead.
   
   Fired with the lust for killing, I grabbed another mouse, and nailed
   him with 175 mg/Kg. Dead in 6 minutes. Another one at 107 mg/Kg. Dead
   in 5 minutes. Another at 75 mg/Kg. Well, he looked pretty sick there
   for a while, and had some shakes, and then he seemed to be pretty much
   OK. One final orgy of murder. I injected 5 mice at 100 mg/Kg i.p., and
   watched four of them die within 20 minutes. I took in my hands the
   sole survivor, and I went outside the laboratory and let him loose on
   the hillside. He scampered away and I never saw him again.
   
   And what did I learn, at the cost of seven precious lives which I can
   never replace? Not a damned thing. Maybe there is an LD-50 somewhere  
   around 60 or 80 mg/Kg. This is for mice, not for men. I was intending
   to take an initial trial dose of 300 micrograms of this completely 
   untested compound, and it would have made no difference to me if the
   LD-50 had been 600 mg/Kg or 6 mg/Kg. I still took my trial dose, and 
   had absolutely no effects, and I never killed another mouse again. No,
   that is simply out-and-out dishonest. I had an invasion of field mice
   last winter coming up through a hole in the floor behind the garbage  
   holder under the kitchen sink, and I blocked the hole, but I also set
   some mouse traps. And I caught a couple. But never again for the
   simple and stupid reasons of being able to say that "This compound has
   an LD-50 in the mouse of 70 mg/Kg." Who cares? Why kill?