From: dmurphy3@aol.com (DMurphy3)
Subject: Methaqualone (Quaalude) Synthesis

Mix 7 g of anthranilic acid, 5 mL of o-toluidine and 4 mL of iron acetate.
Add 40-50 g polyphosphoric acid and heat to 140-160 C over a 25-30 minute
period. Raise the temp. to 180 C for an additional 10 min., then allow to
cool and pour into 150-200 mL distilled water. Neutralize with an aqueous
20% sodium carbonate solution which results in the precipitation of a
resin. This will solidify. Filter off the solution and dissolve the solid
in 25 mL MeOH. Add water dropwise until the solution becomes cloudy. After
about 1 hour the free base methaqualone will precipitate out. Filter the
solution, allow to air dry, then dissolve in just enough MeOH. Add the
calculated amount of concentrated HCl and wait for the salt to crystallize
out. Alternately, you may dissolve the base in ether and bubble dry HCl
through it until no more precipitates. Filter off and allow solvents to
dry throughly before using for any purpose.

In case you wondered, Jason, this was translated from the German from J.
Prakt. Chem. v20, p284, 1963 *and* typed in by yours truly.

Disclaimer: For information purposes only. This is not intended to be used
for any unlawful purpose including, but not limited to, attempting to
synthesize these compounds, attempting to purchase any controlled
sbstances, or sending free samples to the poster.


	    CH3
	    |    Cl
	 N==C     \_____
	/    \    /  _  \
  _____/      N--<  (_)  >  
 /  _  \     /    \_____/
<  (_)  >---C           
 \_____/    ||    methaqualone - the now schedule-1 downer that prior
	    O                    generations knew and loved.

	    CH3
	    |    Cl
	 N==C     \_____
	/    \    /  _  \
  _____/      N--<  (_)  >  
 /  _  \     /    \_____/
<  (_)  >---C           
 \_____/    ||    mecloqualone - Quaalude analog also under schedule-1
	    O